Unilateral choroidal involvement revealing an acute leukemia
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Abstract
A 56-year-old man presented with unilateral subacute visual loss secondary to an exudative serous retinal detachment of the left eye. The clinical course was later complicated by choroidal thickening and uveal effusion. Laboratory investigations revealed acute myeloid leukemia. Systemic chemotherapy was initiated, resulting in regression of the initial ocular findings, while the more typical ocular manifestations associated with leukemia subsequently became apparent. Choroidal infiltration in acute leukemia is rare, particularly as a presenting feature. Retinal abnormalities resolved markedly following successful management of the leukemia, supporting the conclusion that the ocular manifestations were a direct consequence of leukemic infiltration of the choroid.
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References
Kincaid MC, Green WR. Ocular and orbital involvement in leukemia. Surv Ophthalmol 1983;27:211-32. DOI: https://doi.org/10.1016/0039-6257(83)90123-6
Leonardy NJ, Rupani M, Dent G, Klintworth GK. Analysis of 135 autopsy eyes for ocular involvement in leukemia. Am J Ophthalmol 1990;109:436-44. DOI: https://doi.org/10.1016/S0002-9394(14)74610-0
Kishimoto T, Fukuda K, Nishiuchi T, Hayashi N, Fukushima A. Unilateral serous retinal detachment with choroidal thickening as a first presenting sign of acute myeloid leukemia. Am J Ophthalmol Case Rep 2019;14:51-4. DOI: https://doi.org/10.1016/j.ajoc.2019.02.005
Salloukh NA El, Hage DG, Bashshur AZ, Kheir WJ. Early Ophthalmological manifestations of acute myeloid leukemia: current perspectives. Clin Ophthalmol 2022;16:2119-27. DOI: https://doi.org/10.2147/OPTH.S342720
Gordon KB, Rugo HS, Duncan JL, Irvine AR, Howes EL, O’Brien JM, et al. Ocular manifestations of leukemia: leukemic infiltration versus infectious process. Ophthalmology 2001;108:2293-300. DOI: https://doi.org/10.1016/S0161-6420(01)00817-X
Culler AM. Fundus changes in leukemia. Trans Am Soc Ophthalmol Otolaryngol Allergy 1951;49:445-73. DOI: https://doi.org/10.1001/archopht.1951.01700010455011
Talcott KE, Garg RJ, Garg SJ. Ophthalmic manifestations of leukemia. Curr Opin Ophthalmol 2016;27:545-51. DOI: https://doi.org/10.1097/ICU.0000000000000309
Robb RM, Ervin LD, Sallan SE. An autopsy study of eye involvement in acute leukemia of childhood. Med Pediatr Oncol 1979;6:171-7. DOI: https://doi.org/10.1002/mpo.2950060210
Adaniya A, Bazterrechea P, Trucco JI, Schlaen BA, Kusminsky G, Saravia MJ. Bilateral macular detachment: choroid as a sanctuary of acute lymphoblastic leukemia. Am J Ophthalmol Case Reports 2020;19:100746. DOI: https://doi.org/10.1016/j.ajoc.2020.100746
Patel AV, Miller JB, Nath R, et al. Unilateral eye findings: a rare herald of acute leukemia. Ocul Oncol Pathol 2016;2:166-70. DOI: https://doi.org/10.1159/000442951
Naseripour M, Abdolalizadeh P, Abdi F, Mehrvar A, Tashvighi M. Serous retinal detachment as an initial presentation of childhood acute myeloid leukemia. Can J Ophthalmol 2019;54:e170-3. DOI: https://doi.org/10.1016/j.jcjo.2018.10.008