A 14-year-old girl with intermittent headache, palpitations, tachycardia, and diaphoresis

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Vasileios Nikolaos Pililis
John Patrick O'Neill
Iason Mantagos


Pheochromocytomas are neuroendocrine tumors originating from chromaffin cells.  Most arise from the adrenal medulla, while approximately one out of ten cases originate from the extra-adrenal paraganglia. These catecholamine-secreting tumors cause a broad spectrum of symptoms and may resemble various clinical disorders. Their clinical picture varies greatly, from the classic triad of headaches, diaphoresis and palpitations, to asymptomatic tumors discovered incidentally on imaging. We present the case of a 14-year-old girl with pheochromocytoma of adrenal origin and grade IV hypertensive retinopathy and review the clinical picture, follow-up examination, molecular findings and outcome of the 11 reported cases of pheochromocytoma and hypertensive retinopathy in children.


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Pililis VN, O’Neill JP, Mantagos I. A 14-year-old girl with intermittent headache, palpitations, tachycardia, and diaphoresis. Digit J Ophthalmol. 2023;29(2):61-65. doi:10.5693/djo.03.2023.04.003
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Author Biographies

Vasileios Nikolaos Pililis, Athens Medical School

Resident in Ophthalmology.

Department of Ophthalmology, National and Kapodistrian University of Athens, Athens Medical School.

Iason Mantagos, Boston Children's Hospital, Harvard Medical School

Iason Mantagos M.D, PhD. 

Department of Ophthalmology, Boston Children's Hospital

Assistant Professor, Harvard Medical School


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