Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor

Nailyn Rasool; Daniel R. Lefebvre; Mark A. Latina; Ian F. Dunn; Sandro Santagata; Suzanne K. Freitag; Dean M. Cestari

doi:10.5693/djo.02.2017.02.004

On hematoxylin and eosin stained sections, the pathology of the uterine tumor demonstrated spindle-shaped cells with eosinophilic cytoplasm and elongated, cigar-shaped nuclei with mitotic figures and areas of ischemic degeneration (A). The lesion was immunopositive for desmin (B) and smooth muscle actin (C), in keeping with a leiomyosarcoma

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Published: Dec 31, 2017

DOI: https://doi.org/10.5693/djo.02.2017.02.004

Nailyn Rasool, MD, FRCPC

Edward Harkness Eye Institute, Columbia University. New York

Daniel R. Lefebvre, MD

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts

Mark A. Latina, MD

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts

Ian F. Dunn, MD

Department of Neurosurgery. Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

Sandro Santagata, MD, PhD

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School. Boston, Massachusetts

Suzanne K. Freitag, MD

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts

Dean M. Cestari, MD

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts

Abstract

Leiomyosarcomas, neoplasms of smooth muscle, are rarely found within the orbit. Orbital leiomyosarcoma may be primary, metastatic, or secondary to radiation. When they are metastatic, patients almost exclusively have a history of a primary leiomyosarcoma, often occurring in the spermatic cord, skin, gastrointestinal tract, or the uterus. We present the case of 48-year-old woman who presented with a metastatic orbital leiomyosarcoma, which was identified before the primary tumor.

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How to Cite

Rasool N, Lefebvre DR, Latina MA, Dunn IF, Santagata S, Freitag SK, Cestari DM. Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor. Digit J Ophthalmol. 2017;23(4):113-117. doi:10.5693/djo.02.2017.02.004

Issue

Vol. 23 No. 4 (2017)

Section

Case Reports

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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