Extranodal diffuse large B-cell lymphoma in the orbit

Abstract

A 43-year-old man presented at SUNY Downstate Medical Center with a 6-year history of a progressive, painless right globe dystopia. Examination revealed right abaxial proptosis, periorbital fullness, decreased ocular rotations, and conjunctival injection (A). Orbital computed tomography disclosed a large, poorly circumscribed mass in the intra- and extraconal right orbit (B). Biopsy via orbitotomy showed sheets of medium to large lymphocytes (C), which were MUM1+ (D), CD5-, CD10- and kappa restricted, all consistent with diffuse, large B-cell lymphoma, activated B-cell type. Systemic work-up was negative for extraorbital disease, and the patient is currently being considered for chemoradiation.