Original Articles
  Most Recent Cases
  By Volume
  Submit an Original Article.
  Register with DJO to receive personalized updates.

If you're already a
member, please sign in.
Amiodarone Corneal Topography
Digital Journal of Ophthalmology 1997
Volume 3, Number 3
April 30, 1997
Printer Friendly



Steven Patalano, M.D. | Massachusetts Eye and Ear Infirmary, Harvard Medical School
Steven Koenig, M.D. | Medical College of Wisconsin
Robert Hyndiuk, M.D. | Medical College of Wisconsin
Judy Hogatt, M.D. | Medical College of Wisconsin

Abstract
Objective
To study the effects of amiodarone vortex keratopathy on corneal topography.
top
Introduction
Amiodarone is commonly used to treat ventricular arrhythmias refractory to other agents. The ophthalmic side effects of amiodarone treatment are well documented and include a keratopathy characterized by subepithelial corneal whorls similar to those noted in Fabry's Disease and asymptomatic anterior subcapsular lens opacities. Most patients develop the characteristic whorl of rust- colored subepithelial deposits within several months of initiating Amiodarone therapy. The deposits are most prominent inferiorly. Previous studies have shown these changes to completely disappear within 7 months of discontinuing treatment. Symptomatic complaints including halos, decreased vision, and photosensitivity are rare and generally have been attributed to the corneal microdeposits. No studies to date, however, have evaluated Amiodarone Keratopathy using the newer computer operated corneal topography units (figure 1).
top
Figure 1
Eye with Amidodarone vortex kertopathy note the corneal deposits.

Materials and Methods
Four patients with typical Amiodarone Vortex Keratopathy in both eyes underwent EyeSys corneal topography. Each patient had been taking Amiodarone 200 - 400 mg daily for at least 6 months (range 6 to 3 years. Location of corneal deposits FROM amiodarone vortex keratopathy were correlated with findings of corneal topography.
top
Results
Corneal topography of 7 of 8 eyes revealed an unusual irregular astigmatism with generalized mild inferotemporal steepening consistent with the location of the corneal deposits (figure 2,3 ).One eye of 8 did not demonstrate this pattern of irregular astigmatism.
top
Figure 2
EyeSys corneal analysis of patient with amiodarone vortex kertopathy OD.

Figure 3
EyeSys corneal analysis of patient with amiodarone vortex kertopathy OS.

Discussion
This subtle change in corneal topography is probably as important as the subepithelial deposits for the patients' occasional complaints of halos, photophobia and blurry visual acuity. The eye that did not SHOW this astigmatism pattern may represent a slight variation in the typical distribution of subepithelial microdeposits. Further evaluation is necessary to determine if other diseases such as Fabry's which SHOW corneal verticillata will have the same type of corneal topography changes.
top
References
1. Rivera, R.P., Younge, B.R., Dyer, JA.: Atypical Amiodaroneinduced keratopathy in a patient wearing Soft Contact Lenses. CLAC Journal 15(3) :219-21, 1989.

2.Hyatt, R.H., Sinha, B., vallon, A., Bailey, R.J., Martin, A.: Noncardiac side-effects of long-term oral Arniodarone in the elderly. Age & Ageing 17(2):116-22, 1988.

3. Dolan, B.J., Flach, A.J., Peterson, J.S.: Amiodarone keratopathy and lens opacities. Jo Am Optometric Assn 56(6):468-70, 1985.

4 Klingele T.G., Alves, L.E., Rose, E.P.: Amiodarone keratopathy. Ann Ophthalmol 16(12):1172-1176, 1984.

5. Kaplan, L.J., Cappaert, W.E.: Amiodarone-induced corneal deposits. Ann Ophthalmol 16(8):7S2-766, 1984.

6. Harris, L., McKenna, W.J., Rowland, E., Krikler, D.M.. Side effects and possible contraindications of Arniodarone use. Am Heart Jo 106:916-923, 1983.

7. Ingram, DV.: Ocular Effects in long-term Amiodarone therapy. Am Heart Journal 106:902-905, 1983.
top