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Extranodal diffuse large B-cell lymphoma in the orbit
Nov 16, 2017
Volume 23, Number 4
Johnny Li, BS | Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York
Nora Silverman, MD, PhD | Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York
Daniel Diaz, M.D. | Department of Pathology, SUNY Downstate Medical Center, Brooklyn, New York
Raavi Gupta, MD | Department of Pathology, SUNY Downstate Medical Center, Brooklyn, New York
Roman Shinder, MD, FACS | Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York
A 43-year-old man presented at SUNY Downstate Medical Center with a 6-year history of a progressive, painless right globe dystopia. Examination revealed right abaxial proptosis, periorbital fullness, decreased ocular rotations, and conjunctival injection (A). Orbital computed tomography disclosed a large, poorly circumscribed mass in the intra- and extraconal right orbit (B). Biopsy via orbitotomy showed sheets of medium to large lymphocytes (C), which were MUM1+ (D), CD5-, CD10- and kappa restricted, all consistent with diffuse, large B-cell lymphoma, activated B-cell type. Systemic work-up was negative for extraorbital disease, and the patient is currently being considered for chemoradiation.

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