Our patient had CME that could have been secondary to diabetic macular edema (DME), cataract surgery,(1) nanophthalmos,(2,3) or a combination of the above. We decided to treat conservatively with Nepafenac ophthalmic suspension and prednisolone acetate ophthalmic suspension 1%. The patient’s symptoms responded partially to the topical medications, with a persistence of CME and chorioretinal folds. Unfortunately, the patient has been lost to follow-up. Additional considerations were anti-VEGF injections for possible DME, or scleral windows if his condition worsened and did not respond adequately to local treatment.